By Levels, Committee On Acute Exposure Guideline
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Department of the Army 1974). The value was reportedly based on exposure durations of 6-16 min. No additional information is available. 3. S. Department of the Army 1974). The value was reportedly based on exposure durations of 5-30 min. No additional information is available. 4. S. Department of the Army 1974). The value was reportedly based on exposure durations of 5-19 min. No additional information is available. 5. S. Department of the Army 1974). The value was reportedly based on exposure durations of 15-40 min.
70 300 Mydriasis, cycloplegia, ataxia, lethargy, hyperactivity, increased heart rate. 40 500 No effects. 164 8 min 32°F, 63% relative humidity a All effects occurring in dogs at any time during the post-exposure observation period are noted, although not all dogs exhibited all effects. b Study report indicated “no samples”. Source: Ketchum et al. 1967. TABLE 1-7 Effects of Agent BZ on Rabbits Concentration (mg-min/m3) 575 Duration 6 min, 10 sec Conditions 41°F, 67% relative humidity Distance (yards) 100 Effectsa Mydriasis, cycloplegia.
In the absence of definitive concentrationresponse data, this comparison supports the point of departure for development of AEGL-2 values. Agent BZ (3-Quinuclidinyl Benzilate) 29 Data with which to assess the concentration-time relationship for BZ are not available. Experiments conducted by Ketchum and colleagues were of short durations; 6-8 min in animal studies and possibly no more than 5 min in tests with human volunteers. 5 (ten Berge et al. 1986). In the absence of an empirically derived exponent (n) and to obtain protective AEGL values, time scaling was performed using the default of n = 1 to extrapolate to the longer AEGL-specific exposure durations.