By P. Michael Conn
The Receptors, quantity III offers with receptors for interferons, hormones, and progress elements in addition to for ?-aminobutyric acid, tuftsin, somatomedin, and insulin. Prolactin and nicotine receptors also are thought of, in addition to the protein tyrosine kinase task of hormone and progress issue receptors.
Comprised of 12 chapters, this quantity starts with an in depth account of secretory part (SC) as a receptor for polymeric immunoglobulins and the significance of SC-polymeric immunoglobulin A interactions within the mucosal immune approach. The dialogue then turns to interferon receptors and what's identified in regards to the destiny of interferons and their receptors after binding; using muscimol in ligand-binding reviews geared toward characterizing ?-aminobutyric acid receptors; and the function of protease nexins within the interplay of proteases with cells and within the rules of proteolytic job within the interstitial fluid instantly surrounding cells. next chapters specialize in receptor legislation of phosphoinositides and calcium; results of phospholipid turnover on receptor functionality; dynamics of tuftsin receptors; and the constitution, functionality, and rules of somatomedin receptors. The publication additionally examines the internalization and intracellular processing of insulin receptors sooner than concluding with an research of prolactin and nicotine receptors.
This monograph may be a worthwhile source for college students and practitioners in fields starting from mobilephone biology and biochemistry to body structure, endocrinology, and pharmacology.
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Russell, M. , and Mestecky, J. (1982). Hepatobiliary transport of IgA immune complexes: molecular and cellular aspects. J. Immunol. 128, 2183-2186. Brown, W. , Newcomb, R. , and Ishizaka, K. (1970). Proteolytic degradation of exocrine and serum immunoglobulins. J. Clin. Invest. 49, 1374-1380. Brown, W. , and Tada, T. (1972a). Clinical, microbiological and immunological studies in patients with immunoglobulin deficiencies and gastrointestinal disorders. Gut 13, 441-449. Brown, W. , Savage, D. C , Dubois, R.
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Endocytosis and Transcellular Transport of Secretory Component-Immunoglobulin Complexes It is well established that the SC-mediated transport of IgA across epithelial cells or hepatocytes occurs via intracellular transport vesicles (Nagura et al, 1979a; Renston et al, 1980; Takahashi et al, 1982). The transport is specific for polymeric Ig and is initiated by the binding of HRS AFTER INJECTION A in BILE %dose recovered Fig. 8. Radioactivity in blood and bile of rats after the iv injection of 125I-labeled human IgA.